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pentobarbital will reduce the level or effect of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Pitolisant publicity is diminished by 50% if coadministered with robust CYP3A4 inducers.pentobarbital will reduce the level or result of erlotinib by affecting hepatic/intestinal enzyme CYP3A4 metabo